Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite.
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Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systemsSelenium cytotoxicity in cancerA central role for thiols in plant tolerance to abiotic stressJen1p: a high affinity selenite transporter in yeastVariation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapyThe L-cysteine/L-cystine shuttle system provides reducing equivalents to the periplasm in Escherichia coli.Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion.Downregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts.The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Selenium and Human Health: Witnessing a Copernican Revolution?Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies.Redox-active selenium compounds--from toxicity and cell death to cancer treatmentPharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study.Selenium in the prevention of human cancers.Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules.Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanismSelenium in the Therapy of Neurological Diseases. Where is it Going?Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease.Combination of carmustine and selenite effectively inhibits tumor growth by targeting androgen receptor, androgen receptor-variants, and Akt in preclinical models: New hope for patients with castration resistant prostate cancer.Cytotoxic activity of selenosulfate versus selenite in tumor cells depends on cell line and presence of amino acids.Dynamic equilibrium of endogenous selenium nanoparticles in selenite-exposed cancer cells: a deep insight into the interaction between endogenous SeNPs and proteins.Selenium induces a multi-targeted cell death process in addition to ROS formation.Selected ebselen analogs reduce mechlorethamine toxicity in vitro.Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase.Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells.Glutathione serves an extracellular defence function to decrease arsenite accumulation and toxicity in yeast.Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.Responses of an American eel brain endothelial-like cell line to selenium deprivation and to selenite, selenate, and selenomethionine additions in different exposure media.Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels
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Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Extracellular thiol-assisted selenium uptake dependent on the x
@nl
Extracellular thiol-assisted s ...... ific cytotoxicity of selenite.
@en
type
label
Extracellular thiol-assisted selenium uptake dependent on the x
@nl
Extracellular thiol-assisted s ...... ific cytotoxicity of selenite.
@en
prefLabel
Extracellular thiol-assisted selenium uptake dependent on the x
@nl
Extracellular thiol-assisted s ...... ific cytotoxicity of selenite.
@en
P2093
P2860
P356
P1476
Extracellular thiol-assisted s ...... cific cytotoxicity of selenite
@en
P2093
Anna-Klara Rundlöf
Christina Hebert
Erik H Larsen
Mikael Björnstedt
Olof Danielsson
P2860
P304
11400-11405
P356
10.1073/PNAS.0902204106
P407
P577
2009-06-22T00:00:00Z