An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.
about
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/OmiDNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemiaWT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferationKLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin.Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYCGenomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development.A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathwayClassification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferationA genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/β-catenin signaling in mouse embryonic stem cells.Discovery of co-occurring driver pathways in cancerWT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell lineMutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease.Wilms' tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neckβ-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.WT1 expression in the human fetus during development.Wt1 and β-catenin cooperatively regulate diaphragm development in the mouse.Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease.Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axisFunctional characterization of Wilms tumor-suppressor WTX and tumor-associated mutants.Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.A 4-gene expression score associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia.MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.Regulation of HtrA2 on WT1 gene expression under imatinib stimulation and its effects on the cell biology of K562 cellsHtrA2, taming the oncogenic activities of WT1.WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways.Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression.A report of the first international WT1 meeting, University of Manchester UK, 2008.Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor.Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicine Salvia chinensis Benth and its active ingredient protocatechualdehyde.DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and -KTS isoforms-From initial observations to recent global genomic analyses.The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells.
P2860
Q24655084-E26BB226-AFB4-4DD5-A4B5-63A0CCB541A2Q28253465-D95C07AD-A16E-4F93-A453-B2B1896659BCQ28255707-A6488556-CDA9-4517-AFFD-7712A916C665Q33558845-6671003F-EB2B-4F7E-A76B-BF3E4C5E3DC7Q33560429-2BC98736-2692-4E11-BE39-752F0D295553Q33714250-9773C7AF-B8A8-4E54-B98C-B06B8DF02A71Q33825059-07D3FCF8-35EF-4B3C-9390-399BC84C586FQ33847590-2B65DE0B-AB81-4CA0-9364-40F410D62974Q33873840-CB68D047-E733-454E-971E-DB2867B8BF63Q34048409-559BBA3C-DB9E-40C2-957D-E15EC9BB5153Q34710425-2E9D023E-5983-4271-BE93-5F70C12BAD01Q35124213-069B6D0D-FBC2-4FDB-9951-AEBA502E9657Q35575285-9C2F5C83-57B1-4BBD-A8F4-6C5C178BC2CAQ35679310-C9F23D77-E2F1-465F-A47C-7F01F996167EQ35856457-E4937000-C73C-4F4F-AAA0-2349F0915253Q36271500-9BFFB59A-2B88-4823-9D58-3545F4E4BD63Q36908181-073BE2A4-2343-42D1-B123-C15404362304Q38864520-97C5B3A8-E564-49F7-A79C-6F33859D35F5Q39642614-CCA49383-8C71-4A94-8261-F53651CF9029Q39747265-46C6E2A8-FB3D-43BC-A4D6-EA12371F60C4Q40226406-5BFA789F-CCED-4E29-8966-D0D662355F91Q41217413-EACF15AD-BB50-4BAF-AB77-36223E8E9479Q41619009-40848C8C-E0F3-470C-A027-2977D7CA6F47Q42061130-E6F55980-5FF6-49F4-93A2-35EA36AEA33CQ42100794-4E9FB635-6C94-4A44-B190-C414315B287EQ42274969-2A04F2E3-34B8-4E08-AF9D-ABEDA8FB2AF6Q43221537-1151E544-1CC0-4184-BA89-280846A5048EQ46157675-185B0C98-8370-45BC-AB5A-AFE5F9A747EFQ47110433-87234999-F568-4D4C-8D58-BE8708ACB36AQ47120885-8ECEFACA-7CB7-4575-976B-899FA8DA4A8BQ47294532-09138825-0869-40AC-890D-610D510FA76AQ47388677-CA1906A8-9A58-421F-BA17-60791D2F1F03
P2860
An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
An integrated genome screen id ...... hway as a major target of WT1.
@en
An integrated genome screen id ...... hway as a major target of WT1.
@nl
type
label
An integrated genome screen id ...... hway as a major target of WT1.
@en
An integrated genome screen id ...... hway as a major target of WT1.
@nl
prefLabel
An integrated genome screen id ...... hway as a major target of WT1.
@en
An integrated genome screen id ...... hway as a major target of WT1.
@nl
P2093
P2860
P356
P1476
An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1
@en
P2093
Jared M Flatow
Jonathan D Licht
Marianne K-H Kim
Thomas J McGarry
P2860
P304
11154-11159
P356
10.1073/PNAS.0901591106
P407
P577
2009-06-22T00:00:00Z