Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. - Wikidata - awgldk - TriplyDB

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

http://www.wikidata.org/entity/Q37257191

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Tumor angiogenesis: pericytes and maturation are not to be ignored Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go The microenvironment in breast cancer progression: biology and implications for treatment Recent developments in myofibroblast biology: paradigms for connective tissue remodeling Tumor stroma as targets for cancer therapy Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers.Phase II open-label study of sunitinib in patients with advanced breast cancer.Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival.In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells.Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells.Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas.Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer.Anti-proliferative role of recombinant lethal toxin of Bacillus anthracis on primary mammary ductal carcinoma cells revealing its therapeutic potential.Role of receptor tyrosine kinases and their ligands in glioblastoma.Distinctive responsiveness to stromal signaling accompanies histologic grade programming of cancer cells Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes.PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.Peptide-based targeting of the platelet-derived growth factor receptor beta.Targeting the PDGF signaling pathway in tumor treatment PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome.Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer.Stromal expression of β-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer.Stromal LRP1 in lung adenocarcinoma predicts clinical outcome.Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization.A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: a trial of the Princess Margaret Hospital phase II consortium.Tenascin-C, a Prognostic Determinant of Esophageal Squamous Cell Carcinoma Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis.PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial.Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer.Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up.Soluble KIT correlates with clinical outcome in patients with metastatic breast cancer treated with sunitinib Quantum dots-based immunofluorescent imaging of stromal fibroblasts Caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.Selective isolation and characterization of primary cells from normal breast and tumors reveal plasticity of adipose derived stem cells.VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma.Emerging therapeutic targets in metastatic progression: A focus on breast cancer.Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.

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Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

http://www.wikidata.org/entity/Q37257191

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scientific article published on 04 June 2009

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AJPATH.2009.081030

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The American Journal of Pathology

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Prognostic significance of str ...... ession in human breast cancer.

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Arne Ostman

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Carl-Henrik Heldin

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Donal J Brennan

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Göran Landberg

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Janna Paulsson

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Jonas Bergh

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Patrick Micke

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Tobias Sjöblom

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.

Putting tumours in context

PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis

Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting

Fibroblasts in cancer

Tissue microarrays for high-throughput molecular profiling of tumor specimens

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334-341

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scholarly article

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10.2353/AJPATH.2009.081030

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1

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175

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Karin Jirström

Fredrik Pontén

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2009-06-04T00:00:00Z

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26268224

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19498003

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2708819

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