The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
about
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseasesThe PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophilsEthanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol SignalosomeBtk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cellsProstaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator releaseFood allergen--induced mast cell degranulation is dependent on PI3K-mediated reactive oxygen species production and upregulation of store-operated calcium channel subunits.Regulation of mast cell responses in health and disease.The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacementThe mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.DJ-1 regulates mast cell activation and IgE-mediated allergic responses.Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.Tec family kinases: regulation of FcεRI-mediated mast-cell activation.Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils.Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition.Histamine Release from Mast Cells and Basophils.Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide.Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor.Mast cell chemotaxis - chemoattractants and signaling pathways.The protein tyrosine kinase Tec regulates mast cell function.Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells.Potential applications of Bruton's tyrosine kinase inhibitors for the prevention of allergic reactions.Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells
P2860
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P2860
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells
@en
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells.
@nl
type
label
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells
@en
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells.
@nl
prefLabel
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells
@en
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells.
@nl
P2093
P2860
P1476
The phosphoinositide 3-kinase- ...... antigen-stimulated mast cells
@en
P2093
Alasdair M Gilfillan
Dean D Metcalfe
Emily J Swindle
Hye Sun Kuehn
Mi-Sun Kim
Michael A Beaven
P2860
P304
P356
10.4049/JIMMUNOL.181.11.7706
P407
P577
2008-12-01T00:00:00Z