Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Role of the K101E substitution ...... verse transcriptase inhibitors

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Role of the K101E substitution ...... erse transcriptase inhibitors.

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Role of the K101E substitution ...... verse transcriptase inhibitors

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Role of the K101E substitution ...... erse transcriptase inhibitors.

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Role of the K101E substitution ...... verse transcriptase inhibitors

@en

Role of the K101E substitution ...... erse transcriptase inhibitors.

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Role of the K101E substitution ...... verse transcriptase inhibitors

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Hong-Tao Xu

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Mark A Wainberg

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Maureen Oliveira

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Susan P Colby-Germinario

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Wei Huang

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Yingshan Han

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Yudong Quan

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Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Insertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities.

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors

Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.

Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.

Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69.

Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy.

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5649-5657

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scholarly article

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10.1128/AAC.01536-13

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English

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Christos J Petropoulos

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2013-09-03T00:00:00Z

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256424973

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24002090

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3811317

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