Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.
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Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic DiseasesIntracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubesHepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activityPalmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesisMuscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits.Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice.Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.Effect of exercise intensity on unfolded protein response in skeletal muscle of rat.Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanismsStearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes.Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI.Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects.Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivityProtein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signalingSequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicityResveratrol enhances palmitate-induced ER stress and apoptosis in cancer cellsGenetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults.Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice.Genome expression profiling and network analysis of nitrite therapy during chronic ischemia: possible mechanisms and interesting molecules.Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cellsTranscriptional analysis reveals a high impact of conjugated linoleic acid on stearoyl-Coenzyme A desaturase 1 mRNA expression in mice gastrocnemius muscle.Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.Disparate metabolic response to fructose feeding between different mouse strainsStearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis.Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubesTribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.Targeting lipid metabolism for the treatment of anaplastic thyroid carcinoma.Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.Overexpression of stearoyl-CoA desaturase 1 in bone marrow mesenchymal stem cells enhance the expression of induced endothelial cells.Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells.Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism?Stearoyl CoA desaturase 1: role in cellular inflammation and stressThe role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation.S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system.Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.Use antibiotics in cell culture with caution: genome-wide identification of antibiotic-induced changes in gene expression and regulation.The role of ER stress in lipid metabolism and lipotoxicity.
P2860
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P2860
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@en
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@nl
type
label
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@en
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@nl
prefLabel
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@en
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
Individual stearoyl-coa desatu ...... d insulin sensitivity in vivo.
@en
P2093
Andreas Peter
Claus Thamer
Cora Weigert
Erwin Schleicher
Fausto Machicao
Fritz Schick
Jürgen Machann
P2860
P304
P356
10.2337/DB09-0188
P407
P577
2009-05-28T00:00:00Z