The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.

The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.

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http://www.wikidata.org/entity/Q37269228

Q37269228

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Headpiece domain of dematin regulates calcium mobilization and signaling in platelets Agonist-bound structure of the human P2Y12 receptor Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood.Multiscale prediction of patient-specific platelet function under flow Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects A G(i) -independent mechanism mediating Akt phosphorylation in platelets.The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.Anti-platelet therapy: ADP receptor antagonists.P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.Rap1-Rac1 circuits potentiate platelet activation Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production.Synthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents.P2Y12 receptor: platelet thrombus formation and medical interventions.Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products.Cangrelor: A Review in Percutaneous Coronary Intervention.Role of New Antiplatelet Drugs on Cardiovascular Disease: Update on Cangrelor.Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function.Effects of cangrelor in coronary artery disease patients with and without diabetes mellitus: an in vitro pharmacodynamic investigation.Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina.

P2860

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P2860

The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.

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http://www.wikidata.org/entity/Q37269228

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article científic

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scientific article published on 03 April 2009

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