5-Fluorouracil: mechanisms of resistance and reversal strategies. - Wikidata - awgldk - TriplyDB

5-Fluorouracil: mechanisms of resistance and reversal strategies.

5-Fluorouracil: mechanisms of resistance and reversal strategies.

http://www.wikidata.org/entity/Q37270356

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Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation.MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway.Efficacy and safety comparison of chemotherapies for advanced gastric cancer: A network meta-analysis.Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil's cytotoxicity A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells.5-Fluorouracil derivatives: a patent review.Drug resistance in cancer: an overview.Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents Expression of BAF57 in ovarian cancer cells and drug sensitivity.Acquisition of 5-fluorouracil resistance induces epithelial-mesenchymal transitions through the Hedgehog signaling pathway in HCT-8 colon cancer cells Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer Epithelial-mesenchymal Transition is Associated with Acquired Resistance to 5-Fluorocuracil in HT-29 Colon Cancer Cells Effect of low-level laser therapy as an adjuvant in the treatment of periodontitis induced in rats subjected to 5-fluorouracil chemotherapy.Simultaneous Analysis of Wnt and NF-κB Signaling Pathways in Doxorubicin Sensitive and Methotrexate Resistant PLC/ PRF/5 Cells PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting.Cytotoxicity of 5-fluorouracil-loaded pH-sensitive liposomal nanoparticles in colorectal cancer cell lines Predictive markers for the response to 5-fluorouracil therapy in cancer cells: Constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy.Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer.Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse.Dual role of macrophages in the response of C26 colon carcinoma cells to 5-fluorouracil administration.Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo.Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells Novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems.Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery.Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells.Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment.Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice New insights into therapeutic activity and anticancer properties of curcumin.Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues.Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance.5-Fluorouracil derivatives: a patent review (2012 - 2014).

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5-Fluorouracil: mechanisms of resistance and reversal strategies.

http://www.wikidata.org/entity/Q37270356

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 05 August 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@en

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@nl

type

label

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@en

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@nl

prefLabel

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@en

5-Fluorouracil: mechanisms of resistance and reversal strategies.

@nl

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MOLECULES13081551

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5-Fluorouracil: mechanisms of resistance and reversal strategies.

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Ning Zhang

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Sheng-Jie Xu

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Wei-Shan Chen

http://www.w3.org/2001/XMLSchema#string

Ying Yin

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P2860

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity.

Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.

5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs.

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

5-fluorouracil: mechanisms of action and clinical strategies

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

Structure-based studies on species-specific inhibition of thymidylate synthase

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

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1551-1569

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scholarly article

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10.3390/MOLECULES13081551

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8

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23260270

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18794772

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6244944

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