Smac mimetics and innate immune stimuli synergize to promote tumor death - Wikidata - awgldk - TriplyDB

Smac mimetics and innate immune stimuli synergize to promote tumor death

Smac mimetics and innate immune stimuli synergize to promote tumor death

http://www.wikidata.org/entity/Q37270377

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To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses Trial Watch:: Oncolytic viruses for cancer therapy Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?The paradox role of caspase cascade in ionizing radiation therapy Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.IAP antagonists induce anti-tumor immunity in multiple myeloma.Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers.Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.Murine Tumor Models for Oncolytic Rhabdo-Virotherapy.X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity.Opportunities and challenges in combination gene cancer therapy.Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model.Immunotherapeutic potential of oncolytic vaccinia virus.Fighting Cancer with Mathematics and Viruses.Oncolytic Immunotherapy for Treatment of Cancer.Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia.IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics.Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells.Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma.Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics.Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells.Hyperosmotic stress enhances cytotoxicity of SMAC mimetics.IAP antagonization promotes inflammatory destruction of vascular endothelium.Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death.Oncolytic viruses as platform for multimodal cancer therapeutics: a promising land.Oncolytic viruses on the cusp of success?: proceedings of the 9th International Conference on Oncolytic Virus Therapeutics.Inhibitors of apoptosis: clinical implications in cancer.Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses.New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy.PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.Tumor Restrictions to Oncolytic Virus.Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

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Smac mimetics and innate immune stimuli synergize to promote tumor death

http://www.wikidata.org/entity/Q37270377

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 26 January 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Smac mimetics and innate immune stimuli synergize to promote tumor death

@en

Smac mimetics and innate immune stimuli synergize to promote tumor death.

@nl

type

label

Smac mimetics and innate immune stimuli synergize to promote tumor death

@en

Smac mimetics and innate immune stimuli synergize to promote tumor death.

@nl

prefLabel

Smac mimetics and innate immune stimuli synergize to promote tumor death

@en

Smac mimetics and innate immune stimuli synergize to promote tumor death.

@nl

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Nature Biotechnology

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Smac mimetics and innate immune stimuli synergize to promote tumor death

@en

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Caroline E Beauregard

http://www.w3.org/2001/XMLSchema#string

Douglas J Mahoney

http://www.w3.org/2001/XMLSchema#string

Eric C LaCasse

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Fabrice Le Boeuf

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Herman H Cheung

http://www.w3.org/2001/XMLSchema#string

Himika Dastidar

http://www.w3.org/2001/XMLSchema#string

Jan Brun

http://www.w3.org/2001/XMLSchema#string

Janelle Holbrook

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Jeffrey P Nuyens

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Martine St-Jean

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P2860

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Innate immune recognition of viral infection

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas

A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma.

Synergistic interaction between oncolytic viruses augments tumor killing.

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182-190

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scholarly article

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10.1038/NBT.2806

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2

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32

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Carolina S Ilkow

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2014-01-26T00:00:00Z

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24463573

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5030098

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