Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.
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Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancerLectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells.Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.GABA selectively increases mucin-1 expression in isolated pig jejunumBinding of Galectin-3, a β-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell MalignancyPathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.Making Home Sweet and Sturdy: Toxoplasma gondii ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity.Altered tumor-cell glycosylation promotes metastasis.The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.MUC1: a novel metabolic master regulator.Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense.Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.Viewing Siglecs through the lens of tumor immunology.Implication of Soluble Forms of Cell Adhesion Molecules in Infectious Disease and Tumor: Insights from Transgenic Animal Models.Siglec-9 is upregulated in rheumatoid arthritis and suppresses collagen-induced arthritis through reciprocal regulation of Th17-/Treg-cell differentiation.Cell-based glycan arrays for probing glycan-glycan binding protein interactions.Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics.Triple-negative and HER2-overexpressing breast cancer cell sialylation impacts tumor microenvironment T-lymphocyte subset recruitment: a possible mechanism of tumor escape.O-linked mucin-type glycosylation in breast cancerMUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells
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P2860
Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@en
Binding of the sialic acid-bin ...... in and subsequent cell growth.
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type
label
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@en
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@nl
prefLabel
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@en
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@nl
P2093
P2860
P356
P1476
Binding of the sialic acid-bin ...... in and subsequent cell growth.
@en
P2093
Akiko Ishida
Hiroshi Nakada
Kaoru Akita
Kosei Hirakawa
Mariko Ohta
Masakazu Yashiro
Mizue Inoue
Munetoyo Toda
Shuhei Tanida
Tetsuji Sawada
P2860
P304
31842-31852
P356
10.1074/JBC.M113.471318
P407
P577
2013-09-17T00:00:00Z