Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B
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Know the enemy as well as the weapons in hand: the aberrant death pathways and therapeutic agents in chronic lymphocytic leukemiaLysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis.Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration.Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism.Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
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Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Synergistic apoptotic response ...... lysosomal protease cathepsin B
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Synergistic apoptotic response ...... chronic lymphocytic leukaemia
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Synergistic apoptotic response ...... lysosomal protease cathepsin B
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Synergistic apoptotic response ...... chronic lymphocytic leukaemia
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Synergistic apoptotic response ...... lysosomal protease cathepsin B
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Synergistic apoptotic response ...... chronic lymphocytic leukaemia
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P2093
P2860
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P356
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Synergistic apoptotic response ...... lysosomal protease cathepsin B
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P2093
D Szwajcer
J B Johnston
P Benjaminson
P2860
P2888
P356
10.1038/BCJ.2013.50
P577
2013-10-18T00:00:00Z