Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.
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Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic StrategiesCurrent and emerging strategies for the prevention of graft-versus-host diseaseThe Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical OverviewThe Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host DiseaseDeletion of Fanca or Fancd2 dysregulates Treg in miceInterleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host diseaseWhy functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target.The biology of graft-versus-host disease: experimental systems instructing clinical practice.Advances in graft-versus-host disease biology and therapy.Treatment of chronic graft-versus-host disease with bortezomibDonor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras.Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levelsInterleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.HDAC inhibition and graft versus host diseaseInstability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host diseasePrevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen.Anti-IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses.The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with AgeDonor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease.Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation.IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment.Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.Advances in understanding the pathogenesis of graft-versus-host disease.Antigen-presenting cell-derived complement modulates graft-versus-host diseaseIncreased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.Role of interleukin-6 in hemopoietic and non-hemopoietic synergy mediating TLR4-triggered late murine ileus and endotoxic shock.CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity.Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation.Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease.STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.Tocilizumab for steroid refractory acute graft-versus-host diseaseMHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.Essentials of Th17 cell commitment and plasticityA critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.Molecular mechanisms regulating TGF-beta-induced Foxp3 expression.
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P2860
Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 June 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@en
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@nl
type
label
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@en
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@nl
prefLabel
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@en
Blockade of interleukin-6 sign ...... of graft-versus-host disease.
@nl
P2093
P2860
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P1476
Blockade of interleukin-6 sign ...... y of graft-versus-host disease
@en
P2093
Martin J Hessner
Masahiko Mihara
Richard Komorowski
Rupali Das
William R Drobyski
P2860
P304
P356
10.1182/BLOOD-2009-01-197178
P407
P50
P577
2009-06-02T00:00:00Z