Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis - Wikidata - awgldk - TriplyDB

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis

Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis

http://www.wikidata.org/entity/Q37276342

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Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans.Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate.Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD).Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue.Biliary sterol secretion is not required for macrophage reverse cholesterol transport TLR4 and Insulin Resistance.CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance.Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes.Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing.Heterogeneity of the Stearoyl-CoA desaturase-1 (SCD1) gene and metabolic risk factors in the EPIC-Potsdam study.Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome.Fatty liver is associated with transcriptional downregulation of stearoyl-CoA desaturase and impaired protein dimerization.How lipidomics provides new insight into drug discovery.Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells.Impact of murine intestinal apolipoprotein A-IV expression on regional lipid absorption, gene expression, and growth Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity.Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver PPARγ Agonists Attenuate Palmitate-Induced ER Stress through Up-Regulation of SCD-1 in Macrophages.CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.Alteration of Gene Expression Profile in Kidney of Spontaneously Hypertensive Rats Treated with Protein Hydrolysate of Blue Mussel (Mytilus edulis) by DNA Microarray Analysis Fatty acid regulation of hepatic lipid metabolism.Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity.Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice.SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis.

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Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis

http://www.wikidata.org/entity/Q37276342

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article científic

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article scientifique

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bilimsel makale

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scientific article published on 15 September 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Inhibition of stearoyl-coenzym ...... d obesity from atherosclerosis

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Inhibition of stearoyl-coenzym ...... obesity from atherosclerosis.

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type

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Inhibition of stearoyl-coenzym ...... d obesity from atherosclerosis

@en

Inhibition of stearoyl-coenzym ...... obesity from atherosclerosis.

@nl

prefLabel

Inhibition of stearoyl-coenzym ...... d obesity from atherosclerosis

@en

Inhibition of stearoyl-coenzym ...... obesity from atherosclerosis.

@nl

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CIRCULATIONAHA.108.793182

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Inhibition of stearoyl-coenzym ...... d obesity from atherosclerosis

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Amanda L Wibley

http://www.w3.org/2001/XMLSchema#string

Carol Kent

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Chiara Degirolamo

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Heather M Alger

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J Mark Brown

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Janet K Sawyer

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John S Parks

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Kathryn Kelley

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Lawrence L Rudel

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Martha D Wilson

http://www.w3.org/2001/XMLSchema#string

P2860

TLR signaling pathways

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

Stearoyl-CoA desaturase-1 and the metabolic syndrome

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100

TLR4 links innate immunity and fatty acid-induced insulin resistance

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Metabolic syndrome pandemic.

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1467-1475

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scholarly article

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10.1161/CIRCULATIONAHA.108.793182

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14

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118

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2008-09-15T00:00:00Z

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23258131

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18794388

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atherosclerosis

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2716169

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