IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. - Wikidata - awgldk - TriplyDB

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

http://www.wikidata.org/entity/Q37276745

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SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor Phospho-tyrosine dependent protein-protein interaction network The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance Insulin receptor signaling in normal and insulin-resistant states Endoplasmic reticulum stress and the related signaling networks in severe asthma Phosphoinositides: tiny lipids with giant impact on cell regulation Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer.The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases Intracellular signalling. Key enzyme in leptin-induced anorexia Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573 Decreased insulin-dependent glucose transport by chronic ethanol feeding is associated with dysregulation of the Cbl/TC10 pathway in rat adipocytes Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases Identification of the APS protein as a novel insulin receptor substrate Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis Recombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinase A casein kinase I activity is constitutively associated with Nck.T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk.Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn Role of IRS-1-GRB-2 complexes in insulin signaling.Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.

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P2860

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

http://www.wikidata.org/entity/Q37276745

description

1992 nî lūn-bûn

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1992年の論文

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1992年学术文章

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1992年学术文章

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1992年学术文章

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1992年学术文章

@zh-my

1992年学术文章

@zh-sg

1992年學術文章

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1992年學術文章

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1992年學術文章

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name

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@en

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@nl

type

label

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@en

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@nl

prefLabel

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@en

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@nl

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PNAS.89.21.10350

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Proceedings of the National Academy of Sciences of the United States of America

P1476

IRS-1 activates phosphatidylin ...... src homology 2 domains of p85.

@en

P2093

B Schaffhausen

http://www.w3.org/2001/XMLSchema#string

J M Backer

http://www.w3.org/2001/XMLSchema#string

J Schlessinger

http://www.w3.org/2001/XMLSchema#string

M F White

http://www.w3.org/2001/XMLSchema#string

M G Myers

http://www.w3.org/2001/XMLSchema#string

M Yoakim

http://www.w3.org/2001/XMLSchema#string

P Hu

http://www.w3.org/2001/XMLSchema#string

S Shoelson

http://www.w3.org/2001/XMLSchema#string

X J Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

Oncogenes and signal transduction

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.

cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

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10350-10354

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scholarly article

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10.1073/PNAS.89.21.10350

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P433

21

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89

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1992-11-01T00:00:00Z

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21823756

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1332046

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50336

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