Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
about
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expressionCTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin.The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expressionWidespread plasticity in CTCF occupancy linked to DNA methylationCTCF: master weaver of the genomeCTCF-dependent enhancer-blocking by alternative chromatin loop formationAn Overview of Genome Organization and How We Got There: from FISH to Hi-CAntagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locusDose-dependent activation of putative oncogene SBSN by BORISCTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wideDistinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity.Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sitesComplete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethalityFunctional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control regionThe CTCF insulator protein forms an unusual DNA structure.Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Genomic imprinting recapitulated in the human beta-globin locus.Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.Spatial, temporal and interindividual epigenetic variation of functionally important DNA methylation patterns.Genome architecture of the human beta-globin locus affects developmental regulation of gene expressionCTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus.Sequences sufficient for programming imprinted germline DNA methylation defined.Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blockerEpigenetic control of the genome-lessons from genomic imprintingIn the loop: long range chromatin interactions and gene regulation.Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.Oct4/Sox2 binding sites contribute to maintaining hypomethylation of the maternal igf2/h19 imprinting control regionChromosome-wide analysis of parental allele-specific chromatin and DNA methylation.Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1.CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation.Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.A Common Polymorphism within the IGF2 Imprinting Control Region Is Associated with Parent of Origin Specific Effects in Infantile HemangiomasAllele-specific binding of CTCF to the multipartite imprinting control region KvDMR1Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions.Genomic imprinting and epigenetic control of developmentIs there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites.
P2860
Q24295238-92D1FA44-F22C-4B4A-B863-91BE78F482F7Q24309660-6645BA8B-E0BA-4504-8192-68973C65D331Q24316093-6D192E90-E1E6-441B-AD67-CE8FC5AA1E6DQ24544008-BE6D003A-1EFF-4567-9C8E-FEC4469BC4DBQ24608987-87BE1A01-2D1D-4274-88BE-389D39EEE5E7Q24621388-68604B0C-92AA-4A9D-B9B4-2B2ED63E3617Q24646679-8F398FF3-6D71-49C2-9D3E-2E79A070CF2EQ26801741-50D6A542-951C-4EF6-8900-A51F5A8B1C8BQ28473208-BFA0AF7B-FA6A-405F-A6D5-2693568971CAQ28727517-26B9F6DF-4F2E-4143-BC9F-5DEBBA653739Q33268598-9B2A52B9-98DA-44F1-B398-A7052862B668Q33325473-E3FA3A24-ACFA-4229-BDFD-85F9C5EC7168Q33502223-2B3857A0-C4A1-4BB1-A629-36DA4CF5DAC2Q33559752-CF8974E8-3B6F-4D3C-9E3F-B2836811BDDFQ33691538-B60DB103-8A83-47B0-A3AC-6AE5F0BC92C8Q33770481-9504F219-F931-461C-8816-BE16DEA64073Q33777418-B2E434FB-A6D3-42BE-8A64-A0BB6AFBAC70Q33823918-2342D686-535E-40B1-861A-54C279CFE2A0Q33900452-0DFAA8DE-8610-4FBF-8977-E1CF03D9EBF4Q33924215-1585AE54-D27C-4557-BAFA-32ADE8FF1174Q33959408-E8CE1042-2C9F-40C4-9218-06831D1CB6DDQ34097195-018807BD-4E05-4D19-9121-AEBC5FFF3608Q34119785-A62B4353-49E3-4AC1-BA60-47DBB2AEDB87Q34189788-74A6770E-D4A0-4CA3-B42F-9AA2CE7356F8Q34230870-82E618F2-AA00-4683-AF61-CB752ACCB92AQ34347672-722E4812-797E-4731-9CEF-C942BDCD653CQ34580688-8BA639A8-9F75-4C4E-B4B8-C6609E3EED4FQ34834133-1EC87AE0-B8D9-4B9E-BE76-FCC4B5E3AB10Q34918219-FFF4BEE6-F659-4492-BEF9-2294E97C005EQ35064058-19CFB86E-5B3F-4A06-9CA8-FF3EC5FD9A82Q35077074-BBD1AAF1-733E-4B50-9104-67CD357597AEQ35221412-C5A8C23E-2103-4670-9FE9-39C69A65694EQ35595819-2FC3332C-D7FD-4BF1-BD32-B816E6B5BD4DQ35739051-462B51EE-A37F-4266-9B47-D75E3E7D77DBQ35819121-E898403A-EE18-4951-9CC4-F65D5FC94AADQ35856728-E7462DAB-A4E5-4E0F-BEB4-615C5154A0CDQ36034801-B60B776D-87E7-4FE5-8142-A3F9E182DD90Q36065882-C5576940-7B66-440E-9B43-2E773E18CA0AQ36490203-57DEC7A5-1BEA-4B13-A22C-D028058D1634Q36525863-1377FF67-B699-4A45-AC5B-B42C2D592EDF
P2860
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@en
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@nl
type
label
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@en
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@nl
prefLabel
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@en
Mutation of a single CTCF targ ...... ion upon maternal inheritance.
@nl
P2093
P2860
P1476
Mutation of a single CTCF targ ...... tion upon maternal inheritance
@en
P2093
Elena Klenova
Elena Pugacheva
Piero Mariano
Rainer Renkawitz
Rolf Ohlsson
Sreenivasulu Kurukuti
Vinod Pant
P2860
P304
P356
10.1128/MCB.24.8.3497-3504.2004
P407
P577
2004-04-01T00:00:00Z