Formed and preformed metabolites: facts and comparisons.
about
Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models.A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide.Dealing with the complex drug-drug interactions: towards mechanistic models.Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo.Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data.Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling.
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Formed and preformed metabolites: facts and comparisons.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Formed and preformed metabolites: facts and comparisons.
@en
Formed and preformed metabolites: facts and comparisons.
@nl
type
label
Formed and preformed metabolites: facts and comparisons.
@en
Formed and preformed metabolites: facts and comparisons.
@nl
prefLabel
Formed and preformed metabolites: facts and comparisons.
@en
Formed and preformed metabolites: facts and comparisons.
@nl
P2860
P356
P1476
Formed and preformed metabolites: facts and comparisons
@en
P2093
Huadong Sun
Marilyn E Morris
P2860
P304
P356
10.1211/JPP.60.10.0001
P50
P577
2008-10-01T00:00:00Z