Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
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Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage responseA genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stabilityIFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathwayATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repairDNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc fingerATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksMultiple roles of ATM in monitoring and maintaining DNA integrityCHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycleMitochondrial dysfunction in ataxia-telangiectasiaCytoplasmic ATM in neurons modulates synaptic functionDNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and BeyondConnecting Malfunctioning Glial Cells and Brain Degenerative DisordersTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyImpacts of Ionizing Radiation on the Different Compartments of the Tumor MicroenvironmentATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorNot All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation DetectionDiseases associated with defective responses to DNA damageR-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasLow ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.Senescence from G2 arrest, revisitedMolecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-TelangiectasiaHuman Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesionTargeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiationAlterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metforminIdentification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potentialATM-dependent MiR-335 targets CtIP and modulates the DNA damage responseEffect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cyclePARP inhibitor treatment in ovarian and breast cancerGenome-wide association study identifies three new melanoma susceptibility loci.A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationsA rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionPurkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.Autophosphorylation and ATM activation: additional sites add to the complexity.Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.
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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@en
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@nl
type
label
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@en
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@nl
prefLabel
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@en
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@nl
P356
P1476
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.
@en
P2093
Martin F Lavin
P2888
P304
P356
10.1038/NRM2514
P577
2008-10-01T00:00:00Z
P5875
P6179
1009446789