Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.

Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.

Item
http://www.wikidata.org/entity/Q37279290
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewMammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma.Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian CancerAxl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinomaMorphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: pathogRenal cell carcinoma: how to hit the targets?Molecular mechanism mediating cytotoxic activity of axitinib in sunitinib-resistant human renal cell carcinoma cells.HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A.Resistance to the mTOR inhibitor temsirolimus alters adhesion and migration behavior of renal cell carcinoma cells through an integrin α5- and integrin β3-dependent mechanism.Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cells.Cancer Metabolism: a Hope for Curing Cancer.Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.Pan-class I  PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma.Enhanced sensitivity to sorafenib by inhibition of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in vivo.Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours.
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Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.

Item
http://www.wikidata.org/entity/Q37279290
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 October 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@en
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@nl
type
label
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@en
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@nl
prefLabel
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@en
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Acquired resistance to temsiro ...... ction pathways through mTORC2.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932