A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
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Amplification of Cellular Oncogenes in Solid TumorsSingle Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 CellsDiscovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical ModelingThe CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinomaEpithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine.A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas.Prognostic impact of KRAS mutant type and MET amplification in metastatic and recurrent gastric cancer patients treated with first-line S-1 plus cisplatin chemotherapy.Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.RAS signalling in the colorectum in health and disease.Innovative personalized medicine in gastric cancer: time to move forward.Progression inference for somatic mutations in cancer.Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer.Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis.Correlation between MEK signature and Ras gene alteration in advanced gastric cancer.Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma.Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule.Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts.
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A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel method, digital genome ...... gnaling and cancer cell growth
@en
A novel method, digital genome ...... naling and cancer cell growth.
@nl
type
label
A novel method, digital genome ...... gnaling and cancer cell growth
@en
A novel method, digital genome ...... naling and cancer cell growth.
@nl
prefLabel
A novel method, digital genome ...... gnaling and cancer cell growth
@en
A novel method, digital genome ...... naling and cancer cell growth.
@nl
P2093
P2860
P356
P1433
P1476
A novel method, digital genome ...... gnaling and cancer cell growth
@en
P2093
Fumio Aoki
Haruyuki Tatsumi
Hiroaki Mita
Hirofumi Akashi
Hiromu Suzuki
Kazuyoshi Yanagihara
Kohzoh Imai
Lisa Kashima
Masahiro Fujita
Masanobu Kusano
P2860
P2888
P356
10.1186/1471-2407-9-198
P407
P577
2009-06-23T00:00:00Z
P5875
P6179
1001192234