In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
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Artemisinin-resistant malaria: research challenges, opportunities, and public health implicationsArtemisinin-based combination therapies: a vital tool in efforts to eliminate malariaAntimalarial drug resistance: An overviewAntimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR NetworkDrug resistance genomics of the antimalarial drug artemisininIn Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered GrowthPfCRT and its role in antimalarial drug resistanceA genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in KenyaPlasmodium falciparum drug resistance in AngolaTemporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal KenyaCharacterization of drug resistance associated genetic polymorphisms among Plasmodium falciparum field isolates in Ujjain, Madhya Pradesh, IndiaIdentification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparumPfMDR1: mechanisms of transport modulation by functional polymorphismsNovel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistanceThe role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyGenetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum ParasitesAlternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patientsMultiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sitesDrug resistance in eukaryotic microorganisms.Use of proscribed chloroquine is associated with an increased risk of pfcrt T76 mutation in some parts of Ghana.Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data.Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivaxBrazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy.Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia.Directional selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT.Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan.Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective studyEvidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytesSimilar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial.In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.Discovery, mechanisms of action and combination therapy of artemisininDevelopment, evaluation, and application of an in silico model for antimalarial drug treatment and failure.The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, KenyaTemporal and seasonal changes of genetic polymorphisms associated with altered drug susceptibility to chloroquine, lumefantrine, and quinine in Guinea-Bissau between 2003 and 2012Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model.Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs.Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy.Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates.
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P2860
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
In vivo selection of Plasmodiu ...... emether-lumefantrine in Africa
@en
In vivo selection of Plasmodiu ...... mether-lumefantrine in Africa.
@nl
type
label
In vivo selection of Plasmodiu ...... emether-lumefantrine in Africa
@en
In vivo selection of Plasmodiu ...... mether-lumefantrine in Africa.
@nl
prefLabel
In vivo selection of Plasmodiu ...... emether-lumefantrine in Africa
@en
In vivo selection of Plasmodiu ...... mether-lumefantrine in Africa.
@nl
P2093
P2860
P50
P921
P356
P1476
In vivo selection of Plasmodiu ...... emether-lumefantrine in Africa
@en
P2093
Andreas Mårtensson
Christin Sisowath
Ines Petersen
M Isabel Veiga
Zul Premji
P2860
P304
P356
10.1086/596738
P407
P577
2009-03-01T00:00:00Z