Comment on "A common genetic variant is associated with adult and childhood obesity"
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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsThe role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMIA common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease riskAssociation between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly populationGenome-wide association scans identified CTNNBL1 as a novel gene for obesity.Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.Association analysis of positional obesity candidate genes based on integrated data from transcriptomics and linkage analysis.Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sampleAssociation analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 DanesINSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansThe INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Recent progress in the genetics of common obesityFrom monogenic to polygenic obesity: recent advances.Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4RAssociation of INSIG2 polymorphism with overweight and LDL in children.Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing.Genetics of childhood obesityAssociation of the FTO gene with BMI.The Genetics of Pediatric Obesity.On the replication of genetic associations: timing can be everything!Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.Pharmacogenetics of the response to beta 2 agonist drugs: a systematic overview of the field.Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.Calibration of credibility of agnostic genome-wide associations.Multilocus lod scores in large pedigrees: combination of exact and approximate calculationsGenetics of the cardiometabolic syndrome: new insights and therapeutic implications.Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?Challenges in reproducibility of genetic association studies: lessons learned from the obesity field.Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.
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Comment on "A common genetic variant is associated with adult and childhood obesity"
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
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Comment on "A common genetic variant is associated with adult and childhood obesity"
@en
Comment on "A common genetic variant is associated with adult and childhood obesity".
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type
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Comment on "A common genetic variant is associated with adult and childhood obesity"
@en
Comment on "A common genetic variant is associated with adult and childhood obesity".
@nl
prefLabel
Comment on "A common genetic variant is associated with adult and childhood obesity"
@en
Comment on "A common genetic variant is associated with adult and childhood obesity".
@nl
P2860
P50
P356
P1433
P1476
Comment on "A common genetic variant is associated with adult and childhood obesity"
@en
P2093
Stephen O'rahilly
P2860
P304
187; author reply 187
P356
10.1126/SCIENCE.1130012
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P577
2007-01-01T00:00:00Z