Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. - Wikidata - awgldk - TriplyDB

Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells.

Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells.

http://www.wikidata.org/entity/Q37285084

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Predictive biomarkers in precision medicine and drug development against lung cancer Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters Pan-cancer analysis for studying cancer stage using protein expression data Oxidative stress in NSC-741909-induced apoptosis of cancer cells Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380 Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.Development of synthetic lethality anticancer therapeutics.Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380 RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells.Simultaneous determination and validation of oncrasin-266 and its metabolites by HPLC-MS/MS: Application to a pharmacokinetic study RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities.

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P2860

Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells.

http://www.wikidata.org/entity/Q37285084

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 04 May 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@en

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@nl

type

label

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@en

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@nl

prefLabel

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@en

Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@nl

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JBC.M109.010256

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Journal of Biological Chemistry

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Inhibiting JNK dephosphorylati ...... nt NSC-741909 in cancer cells.

@en

P2093

Bingliang Fang

http://www.w3.org/2001/XMLSchema#string

Bo Xu

http://www.w3.org/2001/XMLSchema#string

Jinsong Liu

http://www.w3.org/2001/XMLSchema#string

Li Wang

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Shuhong Wu

http://www.w3.org/2001/XMLSchema#string

Wei Guo

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Xiaoli Wei

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Yiling Lu

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P2860

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

Signal transduction by the JNK group of MAP kinases

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

The concept of synthetic lethality in the context of anticancer therapy

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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16948-16955

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scholarly article

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10.1074/JBC.M109.010256

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25

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2009-05-04T00:00:00Z

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19414586

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apoptotic process

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2719332

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