A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

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http://www.wikidata.org/entity/Q37287446
Emerging regulators of the inflammatory process in osteoarthritisMechanisms and models of endoplasmic reticulum stress in chondrodysplasiaA novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking.Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review).New therapeutic targets in rare genetic skeletal diseases.The chondrocytic journey in endochondral bone growth and skeletal dysplasia.Extracellular matrix and developing growth plate.Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV α5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations.Cartilage oligomeric matrix protein: COMPopathies and beyond.ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice.
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A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

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http://www.wikidata.org/entity/Q37287446
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel transgenic mouse model ...... factor in reduced bone growth.
@en
A novel transgenic mouse model ...... factor in reduced bone growth.
@nl
type
label
A novel transgenic mouse model ...... factor in reduced bone growth.
@en
A novel transgenic mouse model ...... factor in reduced bone growth.
@nl
prefLabel
A novel transgenic mouse model ...... factor in reduced bone growth.
@en
A novel transgenic mouse model ...... factor in reduced bone growth.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
A novel transgenic mouse model ...... factor in reduced bone growth.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932