Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. - Wikidata - awgldk - TriplyDB

Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

http://www.wikidata.org/entity/Q37291393

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Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene Regulation of Nrf2-an update Nrf2 signaling and cell survival Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds Nrf2:INrf2 (Keap1) signaling in oxidative stress Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4).Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice.Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets.Alteration of hepatic but not renal transporter expression in diet-induced obese mice 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway Regulation of hepatic ABCC transporters by xenobiotics and in disease states.Renal efflux transporter expression in pregnant mice with Type I diabetes Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis.Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.Pregnancy represses induction of efflux transporters in livers of type I diabetic mice.LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner.Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease.Applications of genetically modified tools to safety assessment in drug development Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells.New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition.Estrogen potentiates reactive oxygen species (ROS) tolerance to initiate carcinogenesis and promote cancer malignant transformation.Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line.Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance.Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression.Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity.Bimodal role of Kupffer cells during colorectal cancer liver metastasis PPAR Medicines and Human Disease: The ABCs of It All.Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver.Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines.The renin angiotensin system regulates Kupffer cells in colorectal liver metastases.

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Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

http://www.wikidata.org/entity/Q37291393

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scientific article published on 29 August 2008

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Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.

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Toxicological Sciences

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Nrf2- and PPAR alpha-mediated ...... cid and perfluorodecanoic acid

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Curtis D Klaassen

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Jonathan M Maher

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Jose E Manautou

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Matthew Z Dieter

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Yuji Tanaka

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P2860

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

Sources, fate and transport of perfluorocarboxylates

Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS

A comparative toxicological investigation of perfluorocarboxylic acids in rats by fluorine-19 NMR spectroscopy.

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis.

Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia.

Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses.

Regulation of genes encoding NAD(P)H:quinone oxidoreductases.

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10.1093/TOXSCI/KFN177

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2

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Lauren M Aleksunes

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23223885

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18757529

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perfluorodecanoic acid

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