Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.
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A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistryTotal synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesTotal synthesis of (-)-kopsinine and ent-(+)-kopsinineTotal Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubuleUltrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Theoretical insight into the structural mechanism for the binding of vinblastine with tubulin.Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent.Cobalt bis(acetylacetonate)--butyl hydroperoxide-triethylsilane: a general reagent combination for the Markovnikov-selective hydrofunctionalization of alkenes by hydrogen atom transfer
P2860
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P2860
Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
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Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
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Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
@en
Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
@nl
prefLabel
Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
@en
Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
@nl
P2093
P2860
P356
P1476
Potent Vinblastine C20' Ureas ...... ne-Resistant Cancer Cell Line.
@en
P2093
Dale L Boger
Katerina Otrubova
Katharine K Duncan
Timothy J Barker
P2860
P356
10.1021/ML400281W
P577
2013-09-01T00:00:00Z