Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.
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Vaccines against tuberculosis: where are we and where do we need to go?Profiling immunity to HIV vaccines with systems biologyA new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic targetProgress and prospects: immune responses to viral vectorsDecreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccinationPre-existing adenovirus immunity modifies a complex mixed Th1 and Th2 cytokine response to an Ad5/HIV-1 vaccine candidate in humansHIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers.HIV-1 vaccine development after STEP.Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5.Adenovirus-based vaccines: comparison of vectors from three species of adenoviridae.Novel adenovirus vector-based vaccines for HIV-1.New approaches to design HIV-1 T-cell vaccinesCofactors that may influence vaccine responses.Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccineCurrent progress in the development of a prophylactic vaccine for HIV-1.Novel vaccine vectors for HIV-1.Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control study.HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.Lessons drawn from recent HIV vaccine efficacy trials.Effect of preexisting immunity to adenovirus on transgene product-specific genital T cell responses on vaccination of mice with a homologous vectorInduction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humansDNA/NYVAC vaccine regimen induces HIV-specific CD4 and CD8 T-cell responses in intestinal mucosa.Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccineEvolutionarily conserved T-cell epitopes on FIV for designing an HIV/AIDS vaccineSexual risk behaviors, circumcision status, and preexisting immunity to adenovirus type 5 among men who have sex with men participating in a randomized HIV-1 vaccine efficacy trial: step studyPreexisting adenovirus seropositivity is not associated with increased HIV-1 acquisition in three HIV-1 vaccine efficacy trials.Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques.Covalent decoration of adenovirus vector capsids with the carbohydrate epitope αGal does not improve vector immunogenicity, but allows to study the in vivo fate of adenovirus immunocomplexesMerck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity.Characterization of humoral and cellular immune responses elicited by a recombinant adenovirus serotype 26 HIV-1 Env vaccine in healthy adults (IPCAVD 001).DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells.An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible α4β7high CD4+ T cells.Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1.Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors.Lessons learned from HIV vaccine clinical efficacy trials.Advances and future challenges in adenoviral vector pharmacology and targeting.Recent developments for Pseudomonas vaccines.Development of chimpanzee adenoviruses as vaccine vectors: challenges and successes emerging from clinical trials.miRNAs and HIV: unforeseen determinants of host-pathogen interaction.RNA duplexes in transcriptional regulation.
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Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
@en
Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Baseline Ad5 serostatus does n ...... novirus-specific CD4+ T cells.
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Danilo R Casimiro
Diane G Carnathan
George Makedonas
Hildegund C J Ertl
Kara S Cox
Lisa Kierstead
Michael N Robertson
Michael R Betts
Natalie A Hutnick
Sheri A Dubey
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P2888
P304
P356
10.1038/NM.1989
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P577
2009-07-20T00:00:00Z