Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

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http://www.wikidata.org/entity/Q37296982
Targeting Hsp90 in urothelial carcinomaDirect Activation of Bax Protein for Cancer TherapyRegorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cellsCo-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma.Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells.Betulin induces cytochrome c release and apoptosis in colon cancer cells via NOXA.Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis.
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Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

Item
http://www.wikidata.org/entity/Q37296982
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 August 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
@en
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
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type
label
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
@en
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
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prefLabel
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
@en
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
@nl
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Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax
@en
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10.1158/1535-7163.MCT-13-0284
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