A decline in PABPN1 induces progressive muscle weakness in oculopharyngeal muscle dystrophy and in muscle aging
about
Oculopharyngeal muscular dystrophy as a paradigm for muscle aging.Major aging-associated RNA expressions change at two distinct age-positions.PABPN1-Dependent mRNA Processing Induces Muscle Wasting.Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle.Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 AutoregulationBlood RNA expression profiles undergo major changes during the seventh decade.Cytokine genes as potential biomarkers for muscle weakness in OPMD.An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites.Dysfunctional transcripts are formed by alternative polyadenylation in OPMD.Proteasomal activity-based probes mark protein homeostasis in muscles.Functional impact of an oculopharyngeal muscular dystrophy mutation in PABPN1.
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P2860
A decline in PABPN1 induces progressive muscle weakness in oculopharyngeal muscle dystrophy and in muscle aging
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging
@en
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging.
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type
label
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging
@en
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging.
@nl
prefLabel
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging
@en
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging.
@nl
P2093
P2860
P356
P1433
P1476
A decline in PABPN1 induces pr ...... dystrophy and in muscle aging
@en
P2093
Andrea Venema
Barbara van der Sluijs
Baziel G M van Engelen
Jelle J Goeman
John Vissing
Nisha Verway
Seyed Yahya Anvar
P2860
P304
P356
10.18632/AGING.100567
P577
2013-06-01T00:00:00Z