The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
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Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressorMint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerCardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutationHypoxia-inducible factors and the response to hypoxic stressEnergy metabolism in neuroblastoma and Wilms tumorTherapeutic challenges in renal cell carcinomaProtein degradation and the stress responseOxygen levels and the regulation of cell adhesion in the nervous system: a control point for morphogenesis in development, disease and evolution?ARPKD and early manifestations of ADPKD: the original polycystic kidney disease and phenocopiesFunctional interactions among members of the MAX and MLX transcriptional network during oncogenesisPhysiological consequences of complex II inhibition for aging, disease, and the mKATP channelLinking metabolism and epigenetic regulation in development of hepatocellular carcinomaHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionRenal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cystsHIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epitheliumSmall-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1αDissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein InterfaceTargeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α InteractionHIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysisDeclining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during agingRedox regulation of mitochondrial functionModification of the tumor microenvironment as a novel target of renal cell carcinoma therapeuticsSustained proliferation in cancer: Mechanisms and novel therapeutic targetsAssessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesisTargeting heat shock protein 90 for the treatment of malignant pheochromocytomaHypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasisProteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expressionPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionDistinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolismDeletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer.Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxiaHaploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma.Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomasBcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90.Molecular markers of paragangliomas/pheochromocytomasThe von hippel-lindau protein suppresses androgen receptor activity.
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The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@en
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@nl
type
label
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@en
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@nl
prefLabel
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@en
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@nl
P356
P1476
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.
@en
P2888
P304
P356
10.1038/NRC2502
P407
P577
2008-10-16T00:00:00Z
P5875
P6179
1005917553