Protein conformations can be probed in top-down HDX MS experiments utilizing electron transfer dissociation of protein ions without hydrogen scrambling.
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Mass spectrometry-based methods to study protein architecture and dynamicsApplications of hydrogen deuterium exchange (HDX) for the characterization of conformational dynamics in light-activated photoreceptorsIsotope Labeling of Biomolecules: Structural Analysis of Viruses by HDX-MS.Controlling hydrogen scrambling in multiply charged protein ions during collisional activation: implications for top-down hydrogen/deuterium exchange MS utilizing collisional activation in the gas phase.Online Hydrogen-Deuterium Exchange Traveling Wave Ion Mobility Mass Spectrometry (HDX-IM-MS): a Systematic EvaluationMany overlapping peptides for protein hydrogen exchange experiments by the fragment separation-mass spectrometry method.Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX.Exploration of CP12 conformational changes and of quaternary structural properties using electrospray ionization traveling wave ion mobility mass spectrometry.H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach?Enhancing the quality of H/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation.Advantages of isotopic depletion of proteins for hydrogen/deuterium exchange experiments monitored by mass spectrometry.Approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometryA disordered region in the EvpP protein from the type VI secretion system of Edwardsiella tarda is essential for EvpC bindingReal-time hydrogen/deuterium exchange kinetics via supercharged electrospray ionization tandem mass spectrometry.Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriersResolving isotopic fine structure to detect and quantify natural abundance- and hydrogen/deuterium exchange-derived isotopomers.Use of 1,5-diaminonaphthalene to combine matrix-assisted laser desorption/ionization in-source decay fragmentation with hydrogen/deuterium exchange.Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutionsDividing to unveil protein microheterogeneities: traveling wave ion mobility studyNew supercharging reagents produce highly charged protein ions in native mass spectrometry.Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3DETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurementsConformational changes in the G protein Gs induced by the β2 adrenergic receptorTop-down mass spectrometry: recent developments, applications and perspectivesElectrothermal supercharging in mass spectrometry and tandem mass spectrometry of native proteins.Real-time HD Exchange Kinetics of Proteins from Buffered Aqueous Solution with Electrothermal Supercharging and Top-Down Tandem Mass Spectrometry.Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis.A new approach to measuring protein backbone protection with high spatial resolution using H/D exchange and electron capture dissociationConformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry.Anions in electrothermal supercharging of proteins with electrospray ionization follow a reverse Hofmeister series.Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly.The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis.Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution.Analyzing protein dynamics using hydrogen exchange mass spectrometry.Regio-Selective Intramolecular Hydrogen/Deuterium Exchange in Gas-Phase Electron Transfer Dissociation.Top-Down Mass Spectrometry: Proteomics to Proteoforms.Monitoring Conformational Landscape of Ovine Prion Protein Monomer Using Ion Mobility Coupled to Mass Spectrometry.Effects of charge states, charge sites and side chain interactions on conformational preferences of a series of model peptide ions.Minimizing back exchange in the hydrogen exchange-mass spectrometry experiment.Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.
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Protein conformations can be probed in top-down HDX MS experiments utilizing electron transfer dissociation of protein ions without hydrogen scrambling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Protein conformations can be p ...... s without hydrogen scrambling.
@en
Protein conformations can be p ...... s without hydrogen scrambling.
@nl
type
label
Protein conformations can be p ...... s without hydrogen scrambling.
@en
Protein conformations can be p ...... s without hydrogen scrambling.
@nl
prefLabel
Protein conformations can be p ...... s without hydrogen scrambling.
@en
Protein conformations can be p ...... s without hydrogen scrambling.
@nl
P2093
P2860
P1476
Protein conformations can be p ...... ns without hydrogen scrambling
@en
P2093
Desmond A Kaplan
Igor A Kaltashov
Michael L Easterling
P2860
P2888
P304
P356
10.1016/J.JASMS.2009.04.006
P577
2009-04-18T00:00:00Z
P5875
P6179
1047920570