Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer - Wikidata - awgldk - TriplyDB

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

http://www.wikidata.org/entity/Q37307182

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A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus.Ritonavir and ixazomib kill bladder cancer cells by causing ubiquitinated protein accumulation.Recent advances in drug repositioning for the discovery of new anticancer drugs Ritonavir acts synergistically with panobinostat to enhance histone acetylation and inhibit renal cancer growth.Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series.The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin.Breast Cancer in the Setting of HIV Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.Could the FDA-approved anti-HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer.Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin Repositioning HIV protease inhibitors as cancer therapeutics Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells.The impact of nelfinavir exposure on cancer development among a large cohort of HIV-infected patients Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice.Targeting endoplasmic reticulum signaling pathways in cancer.HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?Identifying the optimal dose of ritonavir in the treatment of malignancies.Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelial cells in vitro.Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways.Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism.Breast enlargement in an HIV-infected man on combined antiretroviral therapy: what if it was carcinoma?Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages.p53 and metabolism: from mechanism to therapeutics.

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Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

http://www.wikidata.org/entity/Q37307182

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on March 2006

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Effects of HIV protease inhibi ...... proliferation in breast cancer

@en

Effects of HIV protease inhibi ...... roliferation in breast cancer.

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type

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Effects of HIV protease inhibi ...... proliferation in breast cancer

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Effects of HIV protease inhibi ...... roliferation in breast cancer.

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prefLabel

Effects of HIV protease inhibi ...... proliferation in breast cancer

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Effects of HIV protease inhibi ...... roliferation in breast cancer.

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1078-0432.CCR-05-1167

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Clinical Cancer Research

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Effects of HIV protease inhibi ...... proliferation in breast cancer

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Anjaiah Srirangam

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Christie M Orschell

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David A Potter

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David Donner

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Edward F Srour

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George W Sledge

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Hiromitsu Kishimoto

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John Hawes

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Justin Hamilton

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P2860

PDK1, the master regulator of AGC kinase signal transduction

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

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1883-1896

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scholarly article

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10.1158/1078-0432.CCR-05-1167

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6

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Harikrishna Nakshatri

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2006-03-01T00:00:00Z

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16551874

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