ENU mutagenesis, a way forward to understand gene function.
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Whole-genome profiling of mutagenesis in Caenorhabditis elegansMouse genetic and phenotypic resources for human geneticsObesity genetics in mouse and human: back and forth, and back againCurrent strategies for mutation detection in phenotype-driven screens utilising next generation sequencingModelling age-related metabolic disorders in the mouseControlling complexity: the clinical relevance of mouse complex geneticsENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in miceUnlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutationsNovel gene function revealed by mouse mutagenesis screens for models of age-related disease.Genetic manipulations in the rat: progress and prospects.Mouse models of ciliopathies: the state of the art.Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sitesA mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosisA mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutationA mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathyThe Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven AxisN-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse modelsMice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling PathwayCytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice.Integration of human and mouse genetics reveals pendrin function in hearing and deafnessNew insights into behaviour using mouse ENU mutagenesisA mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping dataNovel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis.A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicityThe low frequency of recessive disease: insights from ENU mutagenesis, severity of disease phenotype, GWAS associations, and demography: an analytical review.Exploiting the power of LINE-1 retrotransposon mutagenesis for identification of genes involved in embryonic stem cell differentiation.Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondiiHigh resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.Pilot study of large-scale production of mutant pigs by ENU mutagenesisA spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha alleleAn N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excessHuman pluripotent stem cells: an emerging model in developmental biology.Inner ear morphology is perturbed in two novel mouse models of recessive deafness.New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice.Functional themes from psychiatric genome-wide screens.Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse.
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ENU mutagenesis, a way forward to understand gene function.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
ENU mutagenesis, a way forward to understand gene function.
@en
ENU mutagenesis, a way forward to understand gene function.
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type
label
ENU mutagenesis, a way forward to understand gene function.
@en
ENU mutagenesis, a way forward to understand gene function.
@nl
prefLabel
ENU mutagenesis, a way forward to understand gene function.
@en
ENU mutagenesis, a way forward to understand gene function.
@nl
P2093
P50
P1476
ENU mutagenesis, a way forward to understand gene function.
@en
P2093
Michelle Kelly
Sara Wells
Steve D M Brown
P356
10.1146/ANNUREV.GENOM.9.081307.164224
P577
2008-01-01T00:00:00Z