A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.
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Emerging preclinical pharmacological targets for Parkinson's diseaseThe involvement of microRNAs in neurodegenerative diseasesNeuronal dark matter: the emerging role of microRNAs in neurodegenerationSNPs in microRNA target sites and their potential role in human diseaseVariants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample.Transcriptome-wide discovery of microRNA binding sites in human brain.RNA metabolism in the pathogenesis of Parkinson׳s diseaseSpecies-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe SyndromeThe impact of 3'UTR variants on differential expression of candidate cancer susceptibility genes.Genome-wide association study confirms extant PD risk loci among the Dutch.Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain.Up-regulation of SNCA gene expression: implications to synucleinopathiesPrecision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons.Current Update on Synopsis of miRNA Dysregulation in Neurological Disorders.Targeting MicroRNAs in Prevention and Treatment of Neurodegenerative Disorders.Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A ReviewDeregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.A search for SNCA 3' UTR variants identified SNP rs356165 as a determinant of disease risk and onset age in Parkinson's disease.α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.The Emerging Role of MitomiRs in the Pathophysiology of Human Disease.Discovering the 3' UTR-mediated regulation of alpha-synuclein.The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease.Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease.A novel extended form of alpha-synuclein 3'UTR in the human brain.
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P2860
A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@en
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@nl
type
label
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@en
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@nl
altLabel
A single nucleotide polymorphi ...... ty locus for Parkinson disease
@en
prefLabel
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@en
A single nucleotide polymorphi ...... y locus for Parkinson disease.
@nl
P2093
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A single nucleotide polymorphi ...... y locus for Parkinson disease.
@en
P2093
Andreas D Baxevanis
Gretchen Gibney
Robert L Nussbaum
Sotiria Sotiriou
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P304
P356
10.1016/J.NEULET.2009.06.034
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P577
2009-06-18T00:00:00Z