Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane
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Gene therapy for the inner earImproved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened CochleaPerilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention.Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs.Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigsTemporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigsCurrent status and prospects of gene therapy for the inner earPrinciples of local drug delivery to the inner ear.Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols.Microperforations significantly enhance diffusion across round window membrane.Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea.Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs.Marker retention in the cochlea following injections through the round window membrane.Enhanced bioavailability of nerve growth factor with phytantriol lipid-based crystalline nanoparticles in cochleaPerilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal.Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigoActivation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea.Issues, indications, and controversies regarding intratympanic steroid perfusionEntry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.Gentamicin concentration gradients in scala tympani perilymph following systemic applications.Variability in the perilymphatic diffusion of gadolinium does not predict the outcome of intratympanic gentamicin in patients with Ménière's disease.Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: systemic versus transtympanic modality.Dexamethasone concentration gradients along scala tympani after application to the round window membrane.Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig.Distribution of gentamicin in inner ear after local administration via a chitosan glycerophosphate hydrogel delivery system.Localization of gentamicin uptake in the acutely isolated inner ear of the rat.An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders.Mannitol and the blood-labyrinth barrier.Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing.In-vitro perforation of the round window membrane via direct 3-D printed microneedles
P2860
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P2860
Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Concentration gradient along t ...... n to the round window membrane
@en
Concentration gradient along t ...... to the round window membrane.
@nl
type
label
Concentration gradient along t ...... n to the round window membrane
@en
Concentration gradient along t ...... to the round window membrane.
@nl
prefLabel
Concentration gradient along t ...... n to the round window membrane
@en
Concentration gradient along t ...... to the round window membrane.
@nl
P2093
P2860
P1433
P1476
Concentration gradient along t ...... n to the round window membrane
@en
P2093
Alec N Salt
Robert Mynatt
Ruth M Gill
Stefan Borgmann
Stefan K Plontke
P2860
P304
P356
10.1097/MLG.0B013E318058A06B
P407
P577
2007-07-01T00:00:00Z