Molecular mechanisms of alpha-synuclein neurodegeneration.
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Prediction of protein binding regions in disordered proteinsParkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitroProtein Oxidation in Aging: Does It Play a Role in Aging Progression?Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Systems biology of neurodegenerative diseasesInhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesAmyloid oligomer neurotoxicity, calcium dysregulation, and lipid raftsNovel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry.Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Parkinson's disease-related protein, alpha-synuclein, in malignant melanomaIntrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Influence of the stability of a fused protein and its distance to the amyloidogenic segment on fibril formation.Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.Proteomics of rat hypothalamus, hippocampus and pre-frontal/frontal cortex after central administration of the neuropeptide PACAP.Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.Analysis of alpha-synuclein in malignant melanoma - development of a SRM quantification assayAlpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress.Structural and dynamical insights into the membrane-bound α-synuclein.Alpha-synuclein transfers from neurons to oligodendrocytes.α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson diseaseInterplay of sequence, topology and termini charge in determining the stability of the aggregates of GNNQQNY mutants: a molecular dynamics study.E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairmentStudies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice.Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17Mitochondrial mutations: newly discovered players in neuronal degeneration.A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeastConditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons.Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies.Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synucleinUnbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.
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Molecular mechanisms of alpha-synuclein neurodegeneration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 October 2008
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Molecular mechanisms of alpha-synuclein neurodegeneration.
@en
Molecular mechanisms of alpha-synuclein neurodegeneration.
@nl
type
label
Molecular mechanisms of alpha-synuclein neurodegeneration.
@en
Molecular mechanisms of alpha-synuclein neurodegeneration.
@nl
altLabel
Molecular mechanisms of α-synuclein neurodegeneration
@en
prefLabel
Molecular mechanisms of alpha-synuclein neurodegeneration.
@en
Molecular mechanisms of alpha-synuclein neurodegeneration.
@nl
P2860
P1476
Molecular mechanisms of alpha-synuclein neurodegeneration.
@en
P2093
Benoit I Giasson
Elisa A Waxman
P2860
P304
P356
10.1016/J.BBADIS.2008.09.013
P407
P577
2008-10-09T00:00:00Z