Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability
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Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-AtherosclerosisArginase induction and activation during ischemia and reperfusion and functional consequences for the heartSelective inhibition of protein kinase C β2 attenuates the adaptor P66 Shc-mediated intestinal ischemia-reperfusion injuryLong term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signalingModerate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway.Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders.ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation.Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity.Arginase: an old enzyme with new tricks.New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases.Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression.Arginase-II Deficiency Extends Lifespan in Mice.Arginase II: atherogenesis beyond enzyme activity.The Impact of Aging on Cardio and Cerebrovascular Diseases.Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs.Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis.Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.
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P2860
Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Arginase-II induces vascular s ...... sclerotic plaque vulnerability
@en
Arginase-II induces vascular s ...... clerotic plaque vulnerability.
@nl
type
label
Arginase-II induces vascular s ...... sclerotic plaque vulnerability
@en
Arginase-II induces vascular s ...... clerotic plaque vulnerability.
@nl
prefLabel
Arginase-II induces vascular s ...... sclerotic plaque vulnerability
@en
Arginase-II induces vascular s ...... clerotic plaque vulnerability.
@nl
P2093
P2860
P356
P1476
Arginase-II induces vascular s ...... sclerotic plaque vulnerability
@en
P2093
Xiu-Fen Ming
Yuyan Xiong
Zhihong Yang
P2860
P304
P356
10.1161/JAHA.113.000096
P577
2013-07-05T00:00:00Z