Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. - Wikidata - awgldk - TriplyDB

Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.

Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.

http://www.wikidata.org/entity/Q37311185

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Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery Phase I dosage finding and pharmacokinetic study of intravenous topotecan and oral erlotinib in adults with refractory solid tumors.Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.Choroid plexus transport: gene deletion studies.Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer.Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex Potent efficacy of metronomic topotecan and pazopanib combination therapy in preclinical models of primary or late stage metastatic triple-negative breast cancer.Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models.Anticancer therapies and CNS relapse: overcoming blood-brain and blood-cerebrospinal fluid barrier impermeability.Efflux transporters in the blood-brain interfaces--in vitro and in vivo methods and correlations.Drug transporters in the central nervous system.Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review.Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model.Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: A direct comparative analysis of icotinib, gefitinib, and erlotinib in a nude mouse model.The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier.

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Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.

http://www.wikidata.org/entity/Q37311185

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bilimsel makale

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scientific article published on 30 June 2009

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vetenskaplig artikel

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vědecký článek

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Compartment-specific roles of ...... chyma and cerebrospinal fluid.

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Compartment-specific roles of ...... chyma and cerebrospinal fluid.

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Compartment-specific roles of ...... chyma and cerebrospinal fluid.

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Compartment-specific roles of ...... chyma and cerebrospinal fluid.

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0008-5472.CAN-09-0700

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Cancer Research

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Compartment-specific roles of ...... chyma and cerebrospinal fluid.

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Angel M Carcaboso

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Christopher M Waters

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Clinton F Stewart

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Henry G Wynn

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John C Panetta

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Jun Shen

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K Elaine Hubbard

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Michael Tagen

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Mohamed A Elmeliegy

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P2860

Analysis of toxicokinetic data using NONMEM: impact of quantification limit and replacement strategies for censored data.

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.

Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain.

Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.

Drug resistance in brain diseases and the role of drug efflux transporters.

Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.

Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride].

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.

Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.

Pharmacokinetic considerations in the treatment of CNS tumours.

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5885-5892

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10.1158/0008-5472.CAN-09-0700

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2009-06-30T00:00:00Z

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