Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
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Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and functionDetermination of sites of U50,488H-promoted phosphorylation of the mouse κ opioid receptor (KOPR): disconnect between KOPR phosphorylation and internalizationEffects of kappa opioid receptors on conditioned place aversion and social interaction in males and femalesSelective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Identification of novel functionally selective κ-opioid receptor scaffolds.Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin AA novel method for analyzing extremely biased agonism at G protein-coupled receptors.Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motifIntrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritusThe G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.Development of functionally selective, small molecule agonists at kappa opioid receptors.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonistFunctional selectivity of GPCR signaling in animals.Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.Biased agonism: An emerging paradigm in GPCR drug discovery.Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment.Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Modulation of serotonin transporter function by kappa-opioid receptor ligands.The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor.Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist.Allosterism within delta opioid-kappa opioid receptor heteromers in peripheral sensory neurons: Regulation of kappa opioid agonist efficacy.Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice.
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Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 17 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Functional selectivity of 6'-g ...... receptors in striatal neurons.
@en
Functional selectivity of 6'-guanidinonaltrindole
@nl
type
label
Functional selectivity of 6'-g ...... receptors in striatal neurons.
@en
Functional selectivity of 6'-guanidinonaltrindole
@nl
prefLabel
Functional selectivity of 6'-g ...... receptors in striatal neurons.
@en
Functional selectivity of 6'-guanidinonaltrindole
@nl
P2093
P2860
P356
P1476
Functional selectivity of 6'-g ...... receptors in striatal neurons.
@en
P2093
Chad E Groer
Cullen L Schmid
Laura M Bohn
P2860
P304
22387-22398
P356
10.1074/JBC.M113.476234
P407
P577
2013-06-17T00:00:00Z