Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.
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Key fibrogenic mediators: old players. Renin–angiotensin systemPotential role of thymosin Beta 4 in liver fibrosisN-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetesHepatic stellate cells express thymosin Beta 4 in chronically damaged liverThymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosisThymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase.A Tobacco-Derived Thymosin β4 Concatemer Promotes Cell Proliferation and Wound Healing in MiceLoss of endogenous thymosin β4 accelerates glomerular disease.Renal disease pathophysiology and treatment: contributions from the rat.Combination treatment with N-acetyl-seryl-aspartyl-lysyl-proline and tissue plasminogen activator provides potent neuroprotection in rats after strokeThe biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis.Causes and pathogenesis of focal segmental glomerulosclerosis.Advances in the basic and clinical applications of thymosin β4.FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase.Preventive and therapeutic effects of thymosin β4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis.Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney FibrosisThymosin-β4 inhibits proliferation and induces apoptosis of hepatic stellate cells through PI3K/AKT pathway.Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models.Fibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?The role of thymosin-β4 in kidney disease.Thymosin β4 Deficiency Exacerbates Renal and Cardiac Injury in Angiotensin-II-Induced Hypertension.Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review).Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease.
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Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
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Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
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type
label
Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
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Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
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prefLabel
Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
@en
Thymosin β4 and its degradatio ...... ive factors in renal fibrosis.
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Thymosin β4 and its degradatio ...... tive factors in renal fibrosis
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Agnes B Fogo
Bongkwon Chun
Diclehan Orhan
Hai-Chun Yang
Nour-Eddine Rhaleb
Oscar A Carretero
Sebastian A Potthoff
Tyler J Brolin
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P2888
P304
P356
10.1038/KI.2013.209
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P577
2013-06-05T00:00:00Z