Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution.
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The effect of age on thymic functionChanges in primary lymphoid organs with agingMolecular control over thymic involution: from cytokines and microRNA to aging and adipose tissueRejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathwaysAging and immune function: molecular mechanisms to interventionsDrivers of age-related inflammation and strategies for healthspan extensionThe anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strainThymic fatness and approaches to enhance thymopoietic fitness in aging.Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution.Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice.Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involutionGhrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathwaysLabel retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus.Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivorsWNT signaling suppression in the senescent human thymus.Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cellsThymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.Mechanisms of immunosenescence: lessons from models of accelerated immune aging.Inhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor CellsThymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.Caloric Restriction and Formalin-Induced Inflammation: An Experimental Study in Rat ModelPremature thymic involution is independent of structural plasticity of the thymic stroma.Impact of Obesity and Metabolic Syndrome on Immunity.Causes, consequences, and reversal of immune system aging.Bone marrow fat and the decline of B lymphopoiesis in rabbitsMetabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit.Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance.Thymus: the next (re)generation.Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.Chronic caloric restriction partially protects against age-related alteration in serum metabolomeLong-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.A role for Peroxisome Proliferator-Activated Receptor Beta in T cell developmentObesity accelerates thymic aging.The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescenceThymus and aging: morphological, radiological, and functional overview.Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes.Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling.Cellular polarity in aging: role of redox regulation and nutrition.
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P2860
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 31 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Inhibition of thymic adipogene ...... age-related thymic involution.
@en
Inhibition of thymic adipogene ...... age-related thymic involution.
@nl
type
label
Inhibition of thymic adipogene ...... age-related thymic involution.
@en
Inhibition of thymic adipogene ...... age-related thymic involution.
@nl
prefLabel
Inhibition of thymic adipogene ...... age-related thymic involution.
@en
Inhibition of thymic adipogene ...... age-related thymic involution.
@nl
P2093
P2860
P356
P1476
Inhibition of thymic adipogene ...... age-related thymic involution.
@en
P2093
Hyunwon Yang
Vishwa Deep Dixit
Yun-Hee Youm
P2860
P304
P356
10.4049/JIMMUNOL.0900562
P407
P577
2009-07-31T00:00:00Z