Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
about
Proteolytic processing of von Willebrand factor by adamts13 and leukocyte proteasesIs the neutrophil a 'prima donna' in the procoagulant process during sepsis?Regulation of thrombosis and vascular function by protein methionine oxidationEssential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.A shear-based assay for assessing plasma ADAMTS13 activity and inhibitors in patients with thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpura: reducing the risk?Blood group O and black race are independent risk factors for thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency.Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.von Willebrand factor: more than a regulator of hemostasis and thrombosis.An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura.ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates.High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpuraAmino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.A model for single-substrate trimolecular enzymatic kinetics.In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall.Phenotypic expression of ADAMTS13 in glomerular endothelial cellsCleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura.Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.Modulation of the von Willebrand factor-dependent platelet adhesion through alternative proteolytic pathwaysNeutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney.Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size.Mechanisms and clinical implications of thrombosis in paroxysmal nocturnal hemoglobinuria.von Willebrand factor: the old, the new and the unknown.Role of fluid shear stress in regulating VWF structure, function and related blood disorders.Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation.Proteinase 3 Induces Neuronal Cell Death Through Microglial Activation.Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.Degradation of platelet-von Willebrand factor complexes by plasmin: an alternative/backup mechanism to ADAMTS13.Oxidized von Willebrand factor is efficiently cleaved by serine proteases from primary granules of leukocytes: divergence from ADAMTS-13.Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure.In vivo von Willebrand factor size heterogeneity in spite of the clinical deficiency of ADAMTS-13.Pathophysiology of thrombotic thrombocytopenic purpura.Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease.
P2860
Q26827966-1EE75E6E-2C36-4BEE-B760-B02C8CBD2982Q26852338-F659EF79-B753-4485-8F42-400CDD6C1656Q26865448-887BFB6A-D073-4876-B7A5-FA7D47CDF609Q30504401-4A2B1358-8414-4C34-BF0F-AEC4ADE5D9F6Q30577627-A73D150C-72E2-4381-A1F2-CAA5C45090ADQ33393728-9F5B2863-82C1-4F2D-9371-08938586FE70Q33393828-E53A6877-CA0F-42AB-BE3C-0E019EC0564CQ33394819-B863898C-CE6D-4294-A227-9439F4D65C2EQ33395774-AD5238B3-762A-4FBA-944F-920F5FFD603FQ33399396-CB4EC930-4B39-4C2B-ADC6-DBED520BAFD0Q33402792-623F1888-5077-4386-A799-A3FCC23C2575Q33408427-BD3FB5DD-8F28-48F1-9E7D-2A7F5723DA01Q33408786-EFA7160F-3CA0-449B-A0CA-4D3158AAE6B9Q33424684-65A81956-6414-4DB2-885A-B4D0E7F1E610Q33427651-C3BD77C5-B7A9-4602-A91D-2B7AFD17CA93Q33435545-B73447CA-694C-4A91-BB08-A09C9E1DEE61Q33747303-8A4581CF-BA53-4C56-AE89-60D4BBDF8620Q33820902-B956F0FE-630C-44A3-9E5A-F2B18FC82868Q33873826-D14D2CEF-613B-4DF3-8B95-9A0CC8D6BBE7Q33948028-DAB646BF-CB30-4E3B-96B7-65A0FA7934C1Q34016608-C6958E72-DABC-42F1-B1B4-FDB48EE90857Q34377532-C60E0D38-479B-4A57-8235-835D8ED7FC17Q35579858-E4DBB999-BF56-4909-888D-3E208570E714Q35661984-CC8A1CC5-BB4E-4E69-A3CE-C84765DC9BE3Q35882061-73EAF259-7A86-4A16-9A0A-2F8844575C20Q36264512-03C82927-66DE-4CD5-AB2E-70BE33F40F7AQ37076408-0CA9F8AB-2875-44B8-9EE2-1A5EBD97F514Q37370132-7D802E94-D893-4A1D-A56A-9AEA79A7BC8FQ37955206-9522B5A5-7E47-491B-A6B6-3F5C5AC121EBQ38047344-E5AF5E07-D549-401C-A9F5-49A3884EAB41Q38645643-20794694-8D16-4BF6-B705-9F59D84BAEB5Q40096407-FA903BC7-4DC2-4529-AB34-B8BAAF103E7DQ40562374-7B4D5250-265C-4BF3-880F-D9D8D4C9FB74Q42099003-8F7A1660-A32C-4446-AAC4-9DC33431AB66Q42389197-18F99F51-9B2A-4C17-B7BB-60D25D03A318Q43774226-948E6478-84C9-40A4-AEEB-902F04331A1DQ44479370-6D6D3B43-4333-4D8C-A3C5-4F29476DEAE5Q47353189-81801CA1-9DD1-4F3B-9CEC-99979729B590Q47999124-E4CC53EB-5861-4B8C-8509-3E2413D8C025Q49605362-B1009C08-306F-4937-A483-A0A7B4310996
P2860
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
@en
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
@nl
type
label
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
@en
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
@nl
prefLabel
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
@en
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
@nl
P2093
P2860
P1433
P1476
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
@en
P2093
Bonnie S Atkinson
Bruce Bedell
George F Johnson
Robert R Montgomery
Thomas J Raife
Wenjing Cao
P2860
P304
P356
10.1182/BLOOD-2009-01-195461
P407
P577
2009-06-18T00:00:00Z