In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.
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Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation.N-terminal protein modification using simple aminoacyl transferase substratesFluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancerSmart hybrid materials by conjugation of responsive polymers to biomacromolecules.Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide libraryIn situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulationProtein-polymer conjugates: synthetic approaches by controlled radical polymerizations and interesting applications.Emerging synthetic approaches for protein-polymer conjugationsOpportunities for multicomponent hybrid hydrogels in biomedical applicationsFunctional virus-based polymer-protein nanoparticles by atom transfer radical polymerization.Protein-polymer conjugation-moving beyond PEGylation.Particle-based technologies for osteoarthritis detection and therapy.Selective N-terminal functionalization of native peptides and proteins.ATRP in the design of functional materials for biomedical applicationsEnhancing Conjugation Yield of Brush Polymer-Protein Conjugates by Increasing Linker Length at the Polymer End-Group.HYDROGEL-BASED NANOCOMPOSITES OF THERAPEUTIC PROTEINS FOR TISSUE REPAIR.Modulating antibody pharmacokinetics using hydrophilic polymers.Drug development: longer-lived proteins.Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.Transiently responsive protein-polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators.From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.Conjugation of siRNA with comb-type PEG enhances serum stability and gene silencing efficiency.Site-Specific Protein Bioconjugation via a Pyridoxal 5'-Phosphate-Mediated N-Terminal Transamination Reaction.Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo.Building nanostructures using RAFT polymerizationMolecular Sieving on the Surface of a Protein Provides Protection Without Loss of ActivityTopological Effects on Globular Protein-ELP Fusion Block Copolymer Self-AssemblyThermo-Switchable Materials Prepared Using the OEGMA-PlatformPhase transitions in concentrated solution self-assembly of globular protein–polymer block copolymersOvercoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeuticsIn situ growth of a thermoresponsive polymer from a genetically engineered elastin-like polypeptideResponsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviourGrowing polymers from peptides and proteins: a biomedical perspectiveUltra-stable hemoglobin–poly(acrylic acid) conjugatesAn Efficient Approach for Preparing Giant Polypeptide Triblock Copolymers by Protein Dimerization
P2860
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P2860
In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@en
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@nl
type
label
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@en
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@nl
prefLabel
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@en
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@nl
P2093
P2860
P356
P1476
In situ growth of a stoichiome ...... tly improved pharmacokinetics.
@en
P2093
Ashutosh Chilkoti
Eric J Toone
J Andrew Mackay
Michael R Zalutsky
Weiping Gao
P2860
P304
15231-15236
P356
10.1073/PNAS.0904378106
P407
P577
2009-08-25T00:00:00Z