Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.
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Systems toxicology of chemically induced liver and kidney injuries: histopathology-associated gene co-expression modulesAdvanced molecular biologic techniques in toxicologic diseasePrediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profilesA novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicityCharacterization of chemically induced liver injuries using gene co-expression modulesPredictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay dataA New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural AlertsPatient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicityLTMap: a web server for assessing the potential liver toxicity by genome-wide transcriptional expression data.Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.Use of transcriptomics in understanding mechanisms of drug-induced toxicityEnrichment with wood blocks does not affect toxicity assessment in an exploratory toxicology model using Sprague-Dawley ratsGinkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered networkGene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.In vitro platforms for evaluating liver toxicity.Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities.A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine.Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals.Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles.Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findingsMicroengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals.Biomarkers for drug-induced liver injury.Quantitative knowledge-based analysis in compound safety assessment.In silico models for drug-induced liver injury--current status.A decade of toxicogenomic research and its contribution to toxicological science.Drug safety testing paradigm, current progress and future challenges: an overview.Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Adverse Outcome Pathways and Drug-Induced Liver Injury Testing.Development of novel tools for the in vitro investigation of drug-induced liver injury.Integrative functional transcriptomic analyses implicate specific molecular pathways in pulmonary toxicity from exposure to aluminum oxide nanoparticles.Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens.Release of (and lessons learned from mining) a pioneering large toxicogenomics database.AhR activation underlies the CYP1A autoinduction by A-998679 in rats.Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle.Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver.Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis.Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.
P2860
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P2860
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Use of toxicogenomics to under ...... rug discovery and development.
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Use of toxicogenomics to under ...... rug discovery and development.
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type
label
Use of toxicogenomics to under ...... rug discovery and development.
@en
Use of toxicogenomics to under ...... rug discovery and development.
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prefLabel
Use of toxicogenomics to under ...... rug discovery and development.
@en
Use of toxicogenomics to under ...... rug discovery and development.
@nl
P2093
P1433
P1476
Use of toxicogenomics to under ...... rug discovery and development.
@en
P2093
Eric A G Blomme
Jeffrey F Waring
P356
10.1016/J.TOXLET.2008.09.017
P577
2008-10-17T00:00:00Z