Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. - Wikidata - awgldk - TriplyDB

Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator.

Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator.

http://www.wikidata.org/entity/Q37326935

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The Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound Healing Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function Macrophage epoxygenase determines a profibrotic transcriptome signature.Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma.A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition.Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors.Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling.Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis Fibrosis in systemic sclerosis: common and unique pathobiology.Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis.Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis.Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis.The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy.Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis.DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms.Noncanonical transforming growth factor beta signaling in scleroderma fibrosis Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.Proteasomal regulation of pulmonary fibrosis.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.PPAR modulation of kinase-linked receptor signaling in physiology and disease.PPARs as therapeutic targets in cardiovascular disease.PAI-1 in tissue fibrosis.Possible strategies for anti-fibrotic drug intervention in scleroderma.Scleroderma therapy: clinical overview of current trends and future perspective.The complex regulation of TGF-β in cardiovascular disease.Molecular basis of organ fibrosis: potential therapeutic approaches.The Role of PPAR Gamma in Systemic Sclerosis.BET Proteins: An Approach to Future Therapies in Transplantation.Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis.

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Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator.

http://www.wikidata.org/entity/Q37326935

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 24 April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@en

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@nl

type

label

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@en

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@nl

prefLabel

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@en

Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

@nl

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Peroxisome proliferator-activa ...... 0 transcriptional coactivator.

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P2093

Asish K Ghosh

http://www.w3.org/2001/XMLSchema#string

John Varga

http://www.w3.org/2001/XMLSchema#string

Jun Wei

http://www.w3.org/2001/XMLSchema#string

Suyeon Kim

http://www.w3.org/2001/XMLSchema#string

Swati Bhattacharyya

http://www.w3.org/2001/XMLSchema#string

Yaacov Barak

http://www.w3.org/2001/XMLSchema#string

Yasuji Mori

http://www.w3.org/2001/XMLSchema#string

P2860

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators

CREB-binding protein and p300 in transcriptional regulation

The mechanisms of action of PPARs

Human Smad3 and Smad4 are sequence-specific transcription activators

Smad transcription factors

Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively

Cyclopentenone prostaglandins: new insights on biological activities and cellular targets

P304

2968-2977

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scholarly article

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10.1096/FJ.08-128736

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9

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23

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2009-04-24T00:00:00Z

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24361170

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19395477

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2735362

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