CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.
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Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model.The role of Bcl-xL in mouse RPE cell survival.CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin.A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys.A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens.Vaccine adjuvants: putting innate immunity to work.Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice.Encapsulating immunostimulatory CpG oligonucleotides in listeriolysin O-liposomes promotes a Th1-type response and CTL activity.Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands.Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits.Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.Use of defined TLR ligands as adjuvants within human vaccines.Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry.Assessing the safety of adjuvanted vaccines.Accelerating next-generation vaccine development for global disease preventionExtracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation.Anti-tumor activity of CpG-ODN aerosol in mouse lung metastases.Development of the CpG Adjuvant 1018: A Case Study.First-in-Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well-Tolerated.Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control.Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system.17β-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner.Toxicopathology of the developing immune system: investigative and development strategies.Intracerebroventricular Administration of a 2'-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain.NGF steers microglia toward a neuroprotective phenotype.
P2860
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P2860
CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 August 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
CpG-containing immunostimulato ...... in rodents but not in humans.
@en
CpG-containing immunostimulato ...... in rodents but not in humans.
@nl
type
label
CpG-containing immunostimulato ...... in rodents but not in humans.
@en
CpG-containing immunostimulato ...... in rodents but not in humans.
@nl
prefLabel
CpG-containing immunostimulato ...... in rodents but not in humans.
@en
CpG-containing immunostimulato ...... in rodents but not in humans.
@nl
P2093
P2860
P356
P1476
CpG-containing immunostimulato ...... in rodents but not in humans.
@en
P2093
Andrew J Leishman
Atul Sathe
Edith M Hessel
Holger Kanzler
Jeremy A Lum
John D Campbell
Marianne J Ratcliffe
Mark McHale
Martyn L Foster
P2860
P304
P356
10.1172/JCI38294
P407
P577
2009-08-10T00:00:00Z