Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

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http://www.wikidata.org/entity/Q37329723
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice.Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain.α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.The Close Encounter Between Alpha-Synuclein and Mitochondria.A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.
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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Item
http://www.wikidata.org/entity/Q37329723
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
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bilimsel makale
@tr
scientific article published on October 2016
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
@en
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
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type
label
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
@en
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
@nl
prefLabel
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
@en
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
@nl
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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
@en
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P2860
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P31
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10.1523/JNEUROSCI.1659-16.2016
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