Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice.
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RNA-binding proteins and gene regulation in myogenesisPathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophyA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophySystematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cellsPeripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcriptsSynergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.Alternative splicing dysregulation secondary to skeletal muscle regeneration.Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy.Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men.Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradationCELFish ways to modulate mRNA decay.Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction.More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases.Myotonic dystrophy mouse models: towards rational therapy development.Repeat expansion diseases: when a good RNA turns bad.CAG repeats mimic CUG repeats in the misregulation of alternative splicing.Neuromuscular junctions are pathological but not denervated in two mouse models of spinal bulbar muscular atrophy.Androgen-dependent impairment of myogenesis in spinal and bulbar muscular atrophy.
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P2860
Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@en
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
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type
label
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@en
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@nl
prefLabel
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@en
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@nl
P2093
P2860
P356
P1476
Altered RNA splicing contribut ...... Kennedy disease knock-in mice.
@en
P2093
Adrienne M Wang
Andrew P Lieberman
Zhigang Yu
P2860
P304
P356
10.1242/DMM.003301
P577
2009-08-19T00:00:00Z