Tra2beta as a novel mediator of vascular smooth muscle diversification.
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Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle DisordersNeuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brainThe expression analysis of Sfrs10 and Celf4 during mouse retinal developmentHost factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replicationLosartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression.A bioinformatic and computational study of myosin phosphatase subunit diversity.Vascular smooth muscle phenotypic diversity and functionTRA2β controls Mypt1 exon 24 splicing in the developmental maturation of mouse mesenteric artery smooth muscleTra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon.Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.Characterization of nuclear localization signals (NLSs) and function of NLSs and phosphorylation of serine residues in subcellular and subnuclear localization of transformer-2β (Tra2β).Myosin phosphatase isoforms as determinants of smooth muscle contractile function and calcium sensitivity of force production.Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing.The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators.Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation.A splice variant of the myosin phosphatase regulatory subunit tunes arterial reactivity and suppresses response to salt loadingTransformer (Tra2β): master regulator of myosin phosphatase alternative splicing and smooth muscle responses to NO/cGMP signaling.
P2860
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P2860
Tra2beta as a novel mediator of vascular smooth muscle diversification.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@en
Tra2beta as a novel mediator of vascular smooth muscle diversification.
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type
label
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@en
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@nl
prefLabel
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@en
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@nl
P2860
P1433
P1476
Tra2beta as a novel mediator of vascular smooth muscle diversification.
@en
P2093
Steven A Fisher
Supriya Shukla
P2860
P304
P356
10.1161/CIRCRESAHA.108.178384
P577
2008-07-31T00:00:00Z