Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesInsulin receptor signaling in normal and insulin-resistant statesRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsStructural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated RasGenome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility lociTissue-specific regulation and function of Grb10 during growth and neuronal commitment.Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisNew role for Grb10 signaling in the pancreas.Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells.Metabolic functions of glucocorticoid receptor in skeletal muscle.Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10.Grb10 is a dual regulator of receptor tyrosine kinase signaling.The genetics of fat distribution.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaGrb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.Growth factor receptor-bound protein 14: a potential new gene associated with oocyte competence.Biochemical and cellular properties of insulin receptor signalling.[Control of insulin signalisation and action by the Grb14 protein].
P2860
Q21131281-9717863C-3999-46F8-B9F1-92E81FDBF74AQ26823171-BE2EAF24-5CE9-42F3-AFC2-12227AA9A79EQ26849720-0F4BA20C-9122-4C8D-B5A8-C4C28B14DEF4Q27665387-445FB8B7-7C3F-416B-B6CB-533DEDA65509Q27679785-6FBD0108-E286-42EF-BA63-1BF4A00B1B9BQ29417126-8EA0C625-9C58-4703-99B2-80070B1642D7Q30653788-BC7B860D-4B88-4F44-AFD0-2E21F152E2B5Q34793925-6E23EE6D-B996-4E54-867E-59DB3A8828EFQ35639252-9E02A2A3-BA6E-476B-B2A2-B99693DF6C82Q35790318-30A0B4DB-289D-40BC-89FE-FE5F4897AFB0Q36410666-147105E0-1BCC-44DC-9480-7A6015045184Q36410769-79A7DDAC-638F-4AB7-BEDE-64415D937A27Q37465872-F06D1785-A27D-4C0C-A930-E05B6D8609BFQ38092488-F3750321-C644-4D18-8ADD-EC51A8133AE1Q38131371-D433FD07-13F2-4C17-B25D-463CD9AE8552Q38178194-16229620-4E3F-4AAC-AAC9-AD53FFABDF2FQ38196270-EA21B95C-63B8-48EE-A82F-878160C725AAQ39225058-7BA9980D-789D-47BA-95C8-3112187C8FC6Q42456312-591106F2-4F87-4CD8-A11A-26C9A1ADB5E4Q44039759-380D88B1-0728-45C6-B05E-414F116ACB17Q45864153-3879C22E-FD05-4457-A0EA-471C24659576Q47703395-F254DE9B-CD06-425E-BBD4-7C930A57C61BQ54324870-4BD0294E-01C7-4F51-82F2-247BE759CD9A
P2860
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dual ablation of Grb10 and Grb ...... naling and glucose homeostasis
@en
Dual ablation of Grb10 and Grb ...... aling and glucose homeostasis.
@nl
type
label
Dual ablation of Grb10 and Grb ...... naling and glucose homeostasis
@en
Dual ablation of Grb10 and Grb ...... aling and glucose homeostasis.
@nl
prefLabel
Dual ablation of Grb10 and Grb ...... naling and glucose homeostasis
@en
Dual ablation of Grb10 and Grb ...... aling and glucose homeostasis.
@nl
P2093
P2860
P50
P921
P356
P1476
Dual ablation of Grb10 and Grb ...... naling and glucose homeostasis
@en
P2093
Ashleigh S Ryan
Gregory J Cooney
Ruth J Lyons
Susan M Beale
P2860
P304
P356
10.1210/ME.2008-0386
P577
2009-06-18T00:00:00Z