Par complex in cancer: a regulator of normal cell polarity joins the dark side.
about
Polarity in mammalian epithelial morphogenesisA Conformational Switch in the CRIB-PDZ Module of Par-6Aberrant overexpression of the cell polarity module scribble in human cancerInvolvement of Girdin in the determination of cell polarity during cell migrationSpatial regulation of VEGF receptor endocytosis in angiogenesisLoss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.A role for the TGFbeta-Par6 polarity pathway in breast cancer progressionMore targets, more pathways and more clues for mutant p53.Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells.The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.Differential regulation of cell-cell contact, invasion and anoikis by hScrib and hDlg in keratinocytesConcise review: polarity in stem cells, disease, and aging.Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.The ability to induce microtubule acetylation is a general feature of formin proteins.A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryoMatrix nanotopography as a regulator of cell function.Annexin A1 attenuates EMT and metastatic potential in breast cancer.Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancerPAR6B is required for tight junction formation and activated PKCζ localization in breast cancerPKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65.Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity.Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.Tight junctions: a barrier to the initiation and progression of breast cancer?Loss of Par3 promotes lung adenocarcinoma metastasis through 14-3-3ζ protein.The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitriesEpithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.PDZ domains: the building blocks regulating tumorigenesis.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Apico-basal polarity complex and cancer.Cell adhesion and polarity in squamous cell carcinoma of the lung.PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.TGFβ-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cellsHuman papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein.Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma.Roles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.Effect of gyromagnetic fields on human prostatic adenocarcinoma cells.Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.High expression of partitioning defective 3-like protein is associated with malignancy in colorectal cancer.
P2860
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P2860
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@en
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@nl
type
label
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@en
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@nl
prefLabel
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@en
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@nl
P2093
P2860
P356
P1433
P1476
Par complex in cancer: a regulator of normal cell polarity joins the dark side.
@en
P2093
S K Muthuswamy
P2860
P2888
P304
P356
10.1038/ONC.2008.340
P407
P577
2008-11-01T00:00:00Z
P5875
P6179
1031243130